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FLASH GENE

Symbol

CNTN3

contributors: npt/ - updated : 06-10-2006

HGNC name	contactin 3 (plasmacytoma associated)
HGNC id	2173

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p26      Physical location : 74.311.721 - 74.570.343
Synonym name	contactin 3
	plasmacytoma-associated neuronal glycoprotein
	brain-derived immunoglobulin superfamily protein 1
Synonym symbol(s)	PANG, BIG1, BIG-1, KIAA1496, PCS

DNA

TYPE	functioning gene
STRUCTURE	258.62 kb     22 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020872 22 - 4997 NP_065923 - 1028 - -

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary       Hearing/Equilibrium ear inner cochlea     Nervous brain       predominantly   brain forebrain cerebral lobe frontal     brain forebrain cerebral lobe occipital     brain hindbrain cerebellum       brain diencephalon amygdala

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	six Ig-like and four FNIII-like extracellular domains,
	a single transmembrane segment (1TM)
	a short cytoplasmic tail

HOMOLOGY

interspecies

homolog to murine Pang

Homologene

FAMILY	immunoglobulin superfamily
	contactin family

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	neural recognition molecule, mediating cell surface interactions during nervous system development
	having some neurite outgrowth-promoting activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with PTPRG (Abdelhakim 2010)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to autism spectrum disorder

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS