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FLASH GENE
Symbol TOMM7 contributors: mct/npt - updated : 14-06-2008
HGNC name translocase of outer mitochondrial membrane 7 homolog (yeast)
HGNC id 21648
Location 7p15.3      Physical location : 22.852.253 - 22.862.421
Synonym name
  • 6.2 kd protein
  • homolog of Tom7 (S. cerevisiae)
  • mitochondrial import receptor subunit TOM7 homolog
  • Synonym symbol(s) TOM7, AD-014
    DNA
    TYPE functioning gene
    STRUCTURE 10.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 746 6.2 55 - Johnston (2002)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Endocrineadrenal gland    
     thyroid   highly
    Lymphoid/Immunetonsils   highly
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • DNAPK phosphorylation site
  • two N-myristoylation motifs
  • mono polymer complex
    HOMOLOGY
    Homologene
    FAMILY
  • Tom7 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • involved in intracellular protein transport
  • may play a role in destabilizing the interactions between the TOM complex and the TOM receptor
  • required for stabilization of the TOM complex
  • CELLULAR PROCESS protein, post translation, targeting
    PHYSIOLOGICAL PROCESS cellular trafficking transport , mitochondrial transport
    PATHWAY
    metabolism
    signaling
    a component
  • small regulatory component of the translocase of the outer mitochondrial membrane
  • C9orf105 as well as TOMM7, were associated with TOMM40 in the TOM complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • complexed with TOM40 and TOM22
  • cell & other
    REGULATION
    Other levels of TOM22 in mitochondria can accelerate the rate of TOMM7 assembly into the mature TOM complex
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS