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FLASH GENE
Symbol KCTD5 contributors: mct - updated : 02-03-2014
HGNC name potassium channel tetramerisation domain containing 5
HGNC id 21423
Location 16p13.3      Physical location : 2.732.494 - 2.759.029
Synonym symbol(s) FLJ20040
DNA
TYPE functioning gene
STRUCTURE 26.54 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2479 - 234 - 2008 18573101
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a K+ channel tetramerisation domain
  • a bric-a-brac, tramtrak and broad complex (BTB) domain that is most similar to the tetramerization domain (T1) of voltage-gated potassium channels
  • same BTB (bric-a-brac, tramtrack, broad complex) domain surface mediates the assembly of five KCTD5 and four voltage-gated K(+) (Kv) channel subunits
  • mono polymer heteromer , tetramer , complex
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • voltage-gated K+ channel activity
  • substrate-specific adaptor for cullin3-based E3 ligases
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to form a K+ channel complex
  • interacted specifically with CUL3, and formed oligomers through its BTB domain (interaction with cullin3 showed that, in addition to the BTB domain, some AAs in the N-terminus of KCTD5 are required for binding to cullin3)
  • KCTD5 or Cullin3 overexpression increased ZNF711 protein stability
  • cell & other
    REGULATION
    activated by upregulated post-transcriptionally in peripheral blood lymphocytes stimulated through the T-cell receptor
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS