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FLASH GENE
Symbol HMGCLL1 contributors: mct - updated : 22-03-2017
HGNC name 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1
HGNC id 21359
Location 6p12.1      Physical location : 55.299.172 - 55.444.012
Synonym name
  • endoplasmic reticulum 3-hydroxymethyl-3-methylglutaryl-CoA lyase
  • Synonym symbol(s) DKFZP434G1411, bA418P12.1, er-cHL
    EC.number 4.1.3.4
    DNA
    TYPE functioning gene
    STRUCTURE 144.84 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2481 - 340 - 2012 22847177
    10 - 2571 - 370 - 2012 22847177
    6 - 2172 - 237 - 2012 22847177
    8 - 2385 - 308 - 2012 22847177
    10 - 2577 - 241 - 2012 22847177
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine    Homo sapiens
     intestinesmall intestineduodenum   Homo sapiens
    Respiratorylung     Homo sapiens
    Urinarykidney     Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal myristoylation motif
  • a HMGL-like region
  • lacks the peroxisomal targeting sequence C(K/R)L present in HMGCL
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    text
  • dual location in the endoplasmic reticulum (ER) and cytosol, but not in mitochondria or peroxisomes
  • basic FUNCTION
  • may have a catalytic activity
  • having metabolic function, mostly at the pulmonary and brain level
  • extramitochondrial hydroxymethylglutaryl-CoA lyase
  • may be an active, extramitochondrial HMG-CoA lyase and may be subject to post-translational myristoylation
  • plausible physiological roles for HMGCLL1 in either lipid biosynthesis and/or energy metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS