protein
| interacts with MAD2L1 |
|
although MAD2L1BP binds to MAD2L1, it promotes the dissociation of CDC20 from BUB1B in MCC |
|
binding of MAD2L1BP to MAD2L1 in mitotic checkpoint complex (MCC) may trigger a conformational change in CDC20 that facilitates its phosphorylation by CDK, and the latter process may promote its dissociation from BUB1B |
|
is a well-known interacting partner of the spindle assembly checkpoint (SAC) effector molecule MAD2L1 |
|
promotes efficient mitotic exit, specifically the metaphase-anaphase transition, by antagonizing MAD2L1 function |
|
is an antagonist of the SAC effector MAD2L1 and promotes silencing of the SAC and mitotic progression |
|
TRIP13, aided by the adapter protein MAD2L1BP, converts the HORMA-family spindle checkpoint protein MAD2L1 from a signaling-active 'closed' conformer to an inactive 'open' conformer |
|
TRIP13, jointly with the MAD2L1BP, promotes the inactivation of the mitotic (spindle assembly) checkpoint by disassembling the mitotic checkpoint complex (MCC) |
|
MAD2L1BP-induced cell death is mediated by interactions with MAD2L1 that lead to its inactivation is potentially applicable in anticancer therapy |
|
MAD2L1 inhibitory protein MAD2L1BP promotes checkpoint inactivation and timely chromosome segregation |
|
MAD2L1BP blocks the MAD2L1-BUB1B interaction and prevents spontaneous clathrin-mediated INSR endocytosis |
|
MAD2L1BP binding to the TRIP13 N-terminal domain positions the disordered MAD2L1 N-terminus for engagement by the TRIP13 "pore loops", which in cells causes spindle assembly checkpoint defects consistent with loss of TRIP13 function |
|
TRIP13-MAD2L1BP intercepts and disassembles free MCC not bound to anaphase-promoting complex/cyclosome (APC/C) through mediating the local unfolding of the MAD2L1 C-terminal region |