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FLASH GENE
Symbol TRAM1 contributors: mct/npt - updated : 07-04-2009
HGNC name translocation associated membrane protein 1
HGNC id 20568
Location 8q13.3      Physical location : 71.485.454 - 71.520.694
Synonym name translocating chain-associating membrane protein
Synonym symbol(s) TRAM, TRAMP, PNAS-8, PRO1292
DNA
TYPE functioning gene
STRUCTURE 34.93 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
mode radiation hybrid
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2805 42.9 374 - Wang (2008)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Hearing/Equilibriumear   highly
Reproductivemale systemtestis  highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a potential N-terminal N-linked glycosylation site
  • TLC (tram/lag1/cln8) domain
  • a C-terminal 60-residue cytosolic portion
  • HOMOLOGY
    Homologene
    FAMILY
  • membrane-associated proteins related to yeast Lag1p family
  • TRAM family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • required for the translocation of secretory proteins across the er membrane
  • couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta (Kagan 2008)
  • plays a role in the dislocation of a membrane glycoprotein (Oresic 2009)
  • functions as a cofactor to promote efficient CMV protein US2- and US11-dependent dislocation of major histocompatibility complex class I heavy chains (Oresic 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of Sec61 preprotein translocon (Wang 2008)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with BCAP31b and SEC61B (Wang 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS