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FLASH GENE
Symbol ZDHHC15 contributors: mct - updated : 28-12-2021
HGNC name zinc finger, DHHC domain containing 15
HGNC id 20342
Corresponding disease
MRX91 mental retardation, X-linked 91
Location Xq13.1      Physical location : 74.588.263 - 74.743.337
Synonym name
  • zinc finger, DHHC-type containing 15
  • palmitoyltransferase ZDHHC15
  • Synonym symbol(s) FLJ31812, MGC119974, MGC119975, MGC119976, MRX91, DHHC15
    EC.number 2.3.1.-/ 2.3.1.225
    DNA
    TYPE functioning gene
    STRUCTURE 154.83 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - - 95 - Mansouri
    lacking exon 4, 2TM domains, loss of DHHC domain
    - - - - 187 - Mansouri
    lacking exon 7, 2 TM domains and DHHC domain
    - - - - 95 - Mansouri
    lacking exons 4 and 7, 2 TM domains, loss of DHHC domain
    - - 882 - 67 - Mansouri
    lacking exons 4 to 12, only one TM domain
    - - 560 - 48 - Mansouri
    only exon 3, no TM or DHHC domain
    11 - 5582 - 328 - 2017 28167757
  • ZDHHC15 b
  • lacking exon 2, 2TM domains and DHHC domain
  • 12 - 5578 - 337 - 2017 28167757
    ZDHHC15 a1
    3 - 850 - 143 - 2017 28167757
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivefemale systemovary   
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a DHHC-type zinc finger
  • two transmembrane domains
  • HOMOLOGY
    interspecies homolog to murine Zdhhc15
    homolog to rattus LOC317235
    Homologene
    FAMILY DHHC palmitoyltransferase family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • may be functioning as a palmitoyl-transferase and involved in cognitive function
  • ZDHHC16 exhibited the highest activity, followed by ZDHHC7 and ZDHHC15
  • involved in regulation of dendrite morphology and excitatory synapse formation
  • ZDHHC15-mediated palmitoylation is a novel regulatory mechanism of dopamine in the striatum
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRX91
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS