protein
| competes with UV radiation resistance associated gene product (UVRAG) for interaction with BCN1, and the complex formation of Barkor and BCN1 is required for their localizations to autophagosomes |
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BECN1 interacting protein (might promote the translocation of BECN1 from the trans-Golgi network to autophagosomes) |
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BECN1 coiled coil domain (CCD) serves as an interaction platform for assembly of distinct ATG14- and UVRAG-containing complexes to modulate PIK3C3 activity |
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directly interacts with BECN1 through its coiled-coil domain and enhances phosphatidylinositol 3-phosphate kinase class III (PI3KC3) activity to induce autophagosome membrane nucleation |
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specifically binds to Snapin and this interaction effectively facilitates endosomal maturation without affecting autophagic cargo degradation |
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actin filaments colocalized with ATG14, BECN1/Beclin1 and PtdIns3P-rich structures, and some of them have a typical omegasome shape stained with the double FYVE domain or ZFYVE1 |
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is a new target gene of FOXOs and the core clock machinery, and this gene plays an important role in hepatic lipid metabolism |
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dictates the differential regulation (either inhibition or activation) of different PIK3C3 complexes in response to glucose starvation |
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ER-resident SNARE protein syntaxin 17 (STX17) binds ATG14 and recruits it to the ER-mitochondria contact site |
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is critical in controlling an autophagy-dependent phosphorylation of BECN1 |
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DACT1 enhances the ATG14-BECN1-PIK3C3 complex formation and PIK3C3 kinase activity |
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NRBF2 may interact with the ATG14-containing BECN1-PIK3C3 protein complex to modulate protein-protein interactions within the complex, leading to suppression of PIK3C3 activity, autophagosome biogenesis, and autophagic flux |
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ATG14 binds to the SNARE core domain of STX17 through its coiled-coil domain, and stabilizes the STX17-SNAP29 binary t-SNARE complex on autophagosomes |
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ATG14-STX17-SNAP29 interaction mediates autophagosome-lysosome tethering and fusion events, thus revealing a novel function of ATG14 in the later steps of the autophagy pathway |
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directly binds to the STX17-SNAP29 binary complex on autophagosomes and promotes STX17-SNAP29-VAMP8-mediated autophagosome fusion with lysosomes |
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USP36 is regulator for the PRKN-dependent mitophagy at least in part via the BECN1-ATG14 pathway |