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FLASH GENE
Symbol SDK2 contributors: mct - updated : 13-02-2008
HGNC name sidekick homolog 2 (chicken)
HGNC id 19308
Location 17q25.1      Physical location : 71.330.523 - 71.640.227
Synonym name Drosophila sidekick-like
Synonym symbol(s) FLJ10832, KIAA1514
DNA
TYPE functioning gene
STRUCTURE 100.00 kb     39 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Lymphoid/Immunelymph node   highly
Reproductivemale systemtestis  highly
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Visualamacrine cell
Visualbipolar cell
Visualganglion cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal sequence
  • six immunoglobulin C2 motifs
  • 13 fibronectin type III motifs
  • a single transmembrane domain, and an approximately 200-amino acid cytoplasmic domain
  • C-terminal hexapeptide, GFSSFV, conserved in all SDKs, and PDZ-binding motif required for both its synaptic localization in photoreceptors and its ability to promote lamina-specific arborization of presynaptic and postsynaptic processes in the inner plexiform layer
  • HOMOLOGY
    interspecies homolog to rattus LOC360652
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as determinant of lamina-specific synaptic connectivity
  • having a structure consistent with its participation in cell-cell interaction during eye development
  • its localization and function require its incorporation into a MAGI1-containing synaptic scaffold
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with DSCAM (direct lamina-specific synaptic connections in vertebrate retina)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS