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FLASH GENE
Symbol TCEA1 contributors: mct - updated : 23-01-2019
HGNC name transcription elongation factor A (SII), 1
HGNC id 11612
Location 8q11.23      Physical location : 54.879.116 - 54.935.008
Synonym name
  • epididymis secretory sperm binding protein
  • transcription factor IIS
  • Synonym symbol(s) GTF2S, TCEA, SII, TF2S, TFIIS
    DNA
    TYPE functioning gene
    STRUCTURE 55.89 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box)
    cytosine-phosphate-guanine/HTF
    motif repetitive sequence   ALU
    text structure
  • two putative GC-box-type consensus sequences,two CCAAT-box consensus sequences and is bounded by an Alu sequence
  • MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    text two potential transcriptional termination signal sequences downstream from the consensus polyadenylation signal are proposed (PARK)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 2784 34 301 - 1993 7626141
  • isoform 1
  • 10 splicing 2721 31.5 280 - 1993 7626141
  • isoform 2
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
     stomach   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic Hydrophilic
    STRUCTURE
    motifs/domains
  • N-terminal domain is not needed for transcriptional activity, a LW motif, predominantly nuclear localized
  • C2C2 zinc finger domain
  • multiple consensus phosphorylation sites
  • HOMOLOGY
    interspecies homolog to murine Tcea1
    homolog to C.elegans T24M10.1
    Homologene
    FAMILY transcription factor S.II family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • stimulating the RNA polymerase II elongation complex
  • role in transcription recovery and re-establishment of the balance between hypo- and hyper-phosphorylated RNAPolII after DNA damage repair
  • may be required to couple transcription to repair by catalyzing the reverse translocation of the arrested polymerase, allowing access of repair proteins to the site of DNA damage
  • is not limiting for the repair of transcription-blocking DNA lesions and thus the present work does not support a role for TCEA1 in transcription-coupled nucleotide excision repair
  • having a positive role in transcription of pro-oncogenic genes, its expression is elevated in various tumors
  • can influence the proliferative potential, survival and differentiation of myeloid cells
  • CELLULAR PROCESS nucleotide, transcription, elongation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • POLR3K, RNA polymerase II in absence of transcription
  • cooperating with a transcriptional activator (EAF2)
  • bind a carrier protein(s) that accomplishes nuclear import
  • key target of RNF20 tumor suppressor activity
  • dual mode of transcriptional repression by RECQL5 that includes structural mimicry of the POLR2A-TCEA1 interaction
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS