basic FUNCTION
| stimulating the RNA polymerase II elongation complex |
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role in transcription recovery and re-establishment of the balance between hypo- and hyper-phosphorylated RNAPolII after DNA damage repair |
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may be required to couple transcription to repair by catalyzing the reverse translocation of the arrested polymerase, allowing access of repair proteins to the site of DNA damage |
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is not limiting for the repair of transcription-blocking DNA lesions and thus the present work does not support a role for TCEA1 in transcription-coupled nucleotide excision repair |
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having a positive role in transcription of pro-oncogenic genes, its expression is elevated in various tumors |
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can influence the proliferative potential, survival and differentiation of myeloid cells |