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FLASH GENE
Symbol RASA2 contributors: - updated : 07-09-2006
HGNC name RAS p21 protein activator 2
HGNC id 9872
Location 3q22-q23      Physical location : 141.205.925 - 141.331.197
Synonym name GTPase-activating protein of RAS
Synonym symbol(s) GAP1M
DNA
TYPE functioning gene
STRUCTURE 125.00 kb     24 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
text with a placenta specific isoform
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 pharynx   highly
Endocrinethyroid   highly
Lymphoid/Immunelymph node   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a pleckstrin (PH) homology domain
  • a GTPase activating protein (signal transduction)
  • RAS-GAP domain
  • two C2 domains
  • a BTK-type zinc finger domain
  • HOMOLOGY
    Homologene
    FAMILY GAP1 family of GTPase-activating proteins
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text perinuclear region
    basic FUNCTION
  • inhibitory regulator of the RAS-cyclic Amp pathway, enhancing the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binds inositol tetrakisphosphate
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS