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FLASH GENE
Symbol TMEM47 contributors: mct - updated : 15-09-2012
HGNC name transmembrane protein 47
HGNC id
Location Xp21.1      Physical location : 34.645.182 - 34.675.405
Synonym name
  • brain cell membrane protein 1
  • transmembrane 4 superfamily member 10
  • Synonym symbol(s) BCMP1, TM4SF10, DKFZP761J17121, DKFZp564E153, MGC32949, FLJ18096
    DNA
    TYPE functioning gene
    STRUCTURE 30.22 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 4068 20 181 - 2001 11472633
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinesmall intestine   
     liver    
    Lymphoid/Immunespleen    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidneynephronrenal capsuleglomeruluslowly Homo sapiens
     kidneytubuleconvoluted tubule lowly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinarypodocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, perinatal
    Text
  • expression of TM4SF10 peaked at postnatal day 4 and was virtually absent in adult kidneys
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four putative transmembrane domains
  • HOMOLOGY
    interspecies ortholog to C- elegans VAB-9
    Homologene
    FAMILY
  • PMP22/EMP/claudin protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • localizes at the basal-most region of podocyte precursors before the capillary loop stage, at some tubule precursors, and at the ureteric bud junction with S-shaped bodies
  • localized to the perinuclear region and translocated to the cell membrane after Cadherin appearance at cell-cell contacts
  • basic FUNCTION
  • functions during differentiation of podocytes and may participate in the maturation of cell junctions from simple adherens junctions to elaborate slit diaphragms
  • claudin-like proteins that function during junctional development
  • claudin-like cell junction protein that is transiently expressed during podocyte development where its expression is downregulated in differentiating podocytes coincident with the appearance of nephrin at the slit diaphragm
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting witrh FYN (may have a regulatory role in suppressing FYN activity)
  • interaction with FYB, a FYN adapter protein expressed in podocytes, and TMEM47 possibly through FYB, may regulate FYN activity
  • cell & other
    REGULATION
    Other its expression is temporally regulated during kidney development
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS