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FLASH GENE
Symbol PPP2R2A contributors: mct - updated : 15-05-2014
HGNC name protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform
HGNC id 9304
Location 8p21.2      Physical location : 26.149.006 - 26.230.193
Synonym name
  • PP2A, subunit B, B55-alpha isoform
  • PP2A, subunit B, R2-alpha isoform
  • Serine/threonine protein phosphatase 2A, 55 KDA regulatory subunit B, alpha isoform
  • Synonym symbol(s) PR55-alpha, B55A, B55ALPHA, PR52A, PR55A
    EC.number 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 81.19 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3945 - 447 - 2010 2066387
    PPP2R2A - variant 1
    - - 3677 - 457 - 2010 2066387
    PPP2R2A - variant 2
    - - 4400 - - less abundant 2010 2066387
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunelymph node   highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • the N terminus is blocked
  • seven WD repeats
  • mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to C.elegans f26e4.1
    intraspecies homolog to PPP2R2B,PPP2R2C
    Homologene
    FAMILY phosphatase 2A regulatory subunit b family
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • modulating substrate selectivity and catalytic activity
  • directing the localization of the catalytic enzyme to a particular compartment
  • regulatory subunit B of protein phosphatase 2A consisting of a common heterodimeric core enzyme, composed of a 36kDa catalytic subunit (subunit C) and a 65kDa constant regulatory subunit (pr65 or subunit a), and associating with a variety of regulatory subunits (including three families of subunits b)
  • specifically regulates PP2A-mediated beta-catenin dephosphorylation and plays an essential role in Wnt signaling
  • implicated in the negative control of cell growth and division
  • is a key regulator of FOXO1 activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • controls beta-catenin phosphorylation and degradation
  • PPP2R2A modulate the phosphorylation status of the retinoblastoma-related protein RBL1 and its activation
  • activates TP53 through direct interaction and dephosphorylation of EDD, a negative regulator of TP53
  • PPP2R2A is required for GJA1 dephosphorlyation during epidermal barrier acquisition
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in non-small cell lung carcinomas
    Susceptibility to prostate carcinoma
    Variant & Polymorphism other
  • somatic deletion rather than germline sequence variants of PPP2R2A may play a more important role to prostate carcinoma susceptibility
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS