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FLASH GENE
Symbol NPTN contributors: mct - updated : 16-10-2017
HGNC name neuroplastin
HGNC id 17867
Location 15q24.1      Physical location : 73.852.344 - 73.925.753
Synonym name
  • stromal cell derived factor receptor 1
  • stromal cell-derived receptor 1
  • Synonym symbol(s) GP55, GP65, SDFR1, SDR1, np65, np55, DKFZp686L2477, MGC102805
    DNA
    TYPE functioning gene
    STRUCTURE 73.41 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 splicing 2094 30.83 278 - 2012 22036663
    variant d
    9 splicing 2454 44.37 398 in human brain is prominently present in cerebellum 2012 22036663
  • variant beta
  • a third Ig domain in the extracellular region
  • 8 - 2105 31.29 282 - 2012 22036663
  • variant alpha
  • two Ig domains
  • 9 - 2442 43.93 394 - 2012 22036663
    variant c
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellum   Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Sdfr1
    homolog to rattus Sdfr1
    Homologene
    FAMILY
  • immunoglobulin superfamily of cell adhesion molecules.
  • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • type I transmembrane protein
  • NPTN specifically co-localizes with GABRA1 and GABRA2 but not with GABRA3 subunits at GABAergic synapses
  • basic FUNCTION
  • may be involved in cell-cell interactions or cell-substrate interactions
  • might contribute to the anchorage of either extra-synaptic or synaptic receptor clusters
  • involved in hippocampal synaptic plasticity
  • is an important regulator of the number and function of synapses in the hippocampus
  • play important roles in a number of key neuronal and synaptic functions including cell adhesion
  • induce neurite outgrowth and play important roles in synaptic maturation and plasticity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with subtypes of GABRA1 in inhibitory synapses
  • NPTN and BSG are obligatory auxiliary subunits of native ATP2B and key regulators of intracellular Ca2+ concentration
  • NPTN and basigin are obligatory subunits of PMCAs that dramatically increase the efficiency of ATP2B1-mediated Ca2+ clearance
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS