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FLASH GENE
Symbol CSE1L contributors: mct - updated : 23-08-2015
HGNC name CSE1 chromosome segregation 1-like (yeast)
HGNC id 2431
Location 20q13.13      Physical location : 47.662.837 - 47.713.484
Synonym name
  • cellular apoptosis susceptibility CAS
  • cellular apoptosis susceptibility protein
  • importin-alpha re-exporter
  • Synonym symbol(s) CAS, CSE1, MGC117283, MGC130036, MGC130037, XPO2
    DNA
    TYPE functioning gene
    STRUCTURE 50.71 kb     25 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - SRC - TOP1 - ADA ADA - SEMG1 - CSE1L - PTPN1 - MC3R - PCK1 - GNAS - EDN3 - qter
    Authors Brinkmann (96)
    RNA
    TRANSCRIPTS type messenger
    text several tissue specific and developmental stage specific isoforms
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 3627 - 971 - 1999 10331944
    24 - 3459 - 915 - 1999 10331944
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly Homo sapiens
     mouthtongue  highly
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
     proliferating cell
    Digestiveepithelial cell Homo sapiens
    Digestivegoblet Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a nuclear localization signal (NLS)
    HOMOLOGY
    interspecies homolog to yeast chromosome segregation gene 1 (CSE1)
    Homologene
    FAMILY CSEL family
    CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text shuttles between the nucleus and the cytoplasm
    basic FUNCTION
  • involved in the cell cycle of mammalian cells and in apoptosis
  • transport factor necessary for recycling of importin-alpha from the nucleus to the cytoplasm
  • associating with a subset of p53 target promoters, cooperating with p53 to activate transcription of these genes by altering histone modification, specifically histone H3 lysine 27
  • regulates the secretion of colorectal cells and may rgulate the metastasis of colorectal cancer
  • may be involved in the "early" and "late" metastasis of tumor cells in tumorigenesis
  • required for the expression of genes promoting invasion and metastasis
  • plays roles in the regulation of the HR activity and in chromosome stability, and is likely responsible for controlling the HR activity by directly interacting with RAD51
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism cofactor
    signaling
    cofactor of p53
    a component
    INTERACTION
    DNA binding to chromatin
    RNA
    small molecule
    protein
  • binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1
  • is a negative regulator of CFTR-dependent fluid secretion
  • CSE1L associates with RAD51 in human cells, and negatively regulates the nuclear protein level of RAD51 under normal conditions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian cancer (pMID: 23948303)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • urinary CSE1L deserves further evaluation for the screening of bladder cancer
  • immunohistochemical staining of nuclear CSE1L may be useful for the prognosis of bladder urothelial carcinomas
  • Therapy target
    ANIMAL & CELL MODELS