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FLASH GENE

Symbol

ARID4B

contributors: mct - updated : 21-08-2010

HGNC name	AT rich interactive domain 4B (RBP1- like)
HGNC id	15550

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q42.3      Physical location : 235.330.210 - 235.491.532
Synonym name	retinoblastoma binding protein 1-like 1
	breast carcinoma-associated antigen BCAA
	RBP1-like protein
	Rb-binding protein homolog
	SIN3A-associated protein 180
Synonym symbol(s)	BCAA, BRCAA1, SAP180, RBP1L1, RBBP1L1, DKFZp313M2420, MGC163290

DNA

TYPE	functioning gene
STRUCTURE	196.00 kb     24 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016374 24 - 6067 147.8 1312 - Fleischer (2003) NM_031371 23 - 5809 137.6 1226 - Fleischer (2003) lacking exon 18, leading to a shorter isoform missing an internal segment compared to isoform 1

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus       lowly Reproductive female system ovary     lowly   male system testis     highly   male system prostate     lowly

cell lineage
cell lines	highly expressed in breast, lung, colon, pancreatic, ovarian carcinomas
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a Tudor domain
	a ARID/BRIGHT DNA binding domain
	two RRM (rna recognition motif) domains

HOMOLOGY

interspecies	ortholog to rattus arid4b
	ortholog to murine Arid4b

Homologene

FAMILY

RBM334 family

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	antigenic epitope (IKPSLGSKK) recognized by IgG antibodies
	may be a molecular marker associated with a broad range of human malignancies
	member of epigenetic complexes regulating genomic imprinting at the PWS/AS domain (Wu 2006)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

components of the mSin3A corepressor complex

INTERACTION

DNA

binding

RNA

binding

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in cancer cells

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

heterozygous deficiency for Rbbp1l1/Arid4b altered epigenetic modifications at the Prader-Willi syndrome -IC with reduced trimethylation of histone H4K20 and H3K9 and reduced DNA methylation, changing the maternal allele toward a more paternal epigenotype (Wu 2006)