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FLASH GENE
Symbol LPAR6 contributors: mct - updated : 11-12-2018
HGNC name lysophosphatidic acid receptor 6
HGNC id 15520
Corresponding disease
WHAR wooly hair, autosomal recessive 1, with or without hypotrichosis
Location 13q14.2      Physical location : 48.985.183 - 49.018.840
Synonym name
  • P2Y purinoceptor 5
  • purinergic receptor 5
  • RB intron encoded G-protein coupled receptor
  • purinergic receptor P2Y, G-protein coupled, 5
  • Synonym symbol(s) P2Y5, GPRU16, P2RY5, ARWH1, HYPT8, LAH3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation
    text
  • in opposite orientation within intron 17 of the RB gene
  • STRUCTURE 43.81 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3043 - 344 - 2015 25589345
    5 - 2561 - 344 - 2015 25589345
    1 - 2512 - 344 - 2015 25589345
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestine     Homo sapiens
    Reproductivefemale systemplacenta  moderately
    Urinarybladder   moderately
     kidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Epithelialabsorptive excretorydigestive epithelium (mucosa)   Homo sapiens
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumenthair follicle cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane regions
  • a N-glycosylation site
  • conjugated GlycoP , LipoP
    HOMOLOGY
    interspecies ortholog to murine P2y5
    Homologene
    FAMILY G-protein coupled receptor 1 family
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    basic FUNCTION
  • acting as a purinergic nucleotide receptor
  • acting as a rhodopsin like activity
  • LPAR6 acts as a G-protein-coupled receptor involved in hair growth
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand LPA
  • G protein-coupled receptor that binds and is activated by lysophosphatidic acid (LPA)
  • LPAR6 activation by LPA, and not FPP, reduced intestinal cell adhesion
  • cell & other
    REGULATION
    activated by adenosine and uridine nucleotides
    ASSOCIATED DISORDERS
    corresponding disease(s) WHAR
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma associated with poor survival
    Susceptibility to peripheral arterial disease
    Variant & Polymorphism other 93T allele had lower Lp(a) levels and was significantly higher in control subjectsthan in peripheral arterial disease
    Candidate gene
    Marker
    Therapy target for the treatment of excessive or unwanted hair
    ANIMAL & CELL MODELS