basic FUNCTION
| playing a role in transcriptional regulation, forming a complex with the RNA polymerase II |
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histone methyltransferase involved in the proliferation of cancer cells |
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could promote breast carcinogenesis by directly regulating expression of the proto-oncogene WNT10B |
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implicated in oncogenesis, and directly trans-activates the telomerase reverse transcriptase (TERT) gene that is essential for cellular immortalization and transformation |
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required for maintenance of histone H3-K4 trimethylation, there by contributing to inducible and constitutive TERT expression in normal and malignant cells |
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histone H3-lysine 4-specific methyltransferase, involved in the regulation of gene expression and DNA replication through alteration of chromatin structure |
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as a new coactivator for ER-mediated transcription, providing a possible link between SMYD3 overexpression and breast cancer |
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pivotal role for SMYD3 in the regulation of oncogenic RAS signalling |
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plays an important role in early embryonic lineage commitment and peri-implantation development through the activation of lineage-specific genes |
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transcription-potentiating function of SMYD3 is restricted to a particular set of genes, whose expression is induced specifically during carcinogenesis |
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is a SET domain-containing N-lysine methyltransferase associated with multiple cancer |
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is a kind of histone lysine methyltransferase, responsible for transcriptional activation as a member of an RNA polymerase complex |