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FLASH GENE
Symbol DPP7 contributors: - updated : 17-03-2004
HGNC name dipeptidylpeptidase 7
HGNC id 14892
Location 9q34.3      Physical location : 140.004.992 - 140.009.195
Synonym name
  • carboxytripeptidase
  • dipeptidyl arylamidase II
  • dipeptidyl aminopeptidase II
  • dipeptidyl-peptidase II precursor
  • quiescent cell proline dipeptidase; likely ortholog of rat kidney dipeptidyl peptidase II
  • Synonym symbol(s) DPPII, QPP, DPP2
    EC.number 3.4.14.2
    DNA
    TYPE functioning gene
    STRUCTURE 4.00 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    peptidase S28 motif
    secondary structure N-glycosylated protein
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to rattus Dpp7
    intraspecies homolog to PCP
    Homologene
    FAMILY DASH protein
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • prolylcarboxypeptidase activity
  • plays an important role in the degradation of collagen and some oligopeptides, releasing a N-terminal dipeptide
  • active at both acidic and neutral pH
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by Lys-thiazolidide and Lys-piperidide
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS