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FLASH GENE
Symbol PLEKHA3 contributors: mct - updated : 19-09-2018
HGNC name pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3
HGNC id 14338
Location 2q31.2      Physical location : 179.345.198 - 179.369.780
Synonym name
  • four-phosphate-adaptor protein 1
  • phosphatidylinositol-four-phosphate adapter protein 1
  • Synonym symbol(s) FAPP1, FLJ20067
    DNA
    TYPE functioning gene
    STRUCTURE 35.87 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2516 - 300 - 2014 24462251
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon lowly
    Nervousbrain   lowly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a pleckstrin homology (PH) domain, with a ARF1 binding site on PLEKHA3-PH distinct from a positively charged phosphatidylinositol-4-phosphate (PI4P) binding site
  • a proline-rich putative SH3-binding motif
  • HOMOLOGY
    interspecies homolog to murine Plekha3
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • is recruited to the Golgi through binding of its pleckstrin homology (PH) domain to phosphatidylinositol 4-phosphate (PtdIns(4)P) and a small GTPase ADP-ribosylation factor 1 (ARF1)
  • basic FUNCTION
  • effector of phosphatidylinositol 4 phosphate (PI4P)
  • component of the machinery regulated by PI4P and ADP-ribosylation factor (ARF) that controlsthe generation of post-Golgi carriers
  • PLEKHA3, PLEKHA8 are essential components of a PtdIns(4)P- and ARF-regulated machinery that controls generation of constitutive post-Golgi carriers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
    interacts with PI4P
    protein
  • interaction of PLEKHA3 with ARF1 and PI4P at a membrane surface
  • cell & other
    REGULATION
    Other PI4P and ARf regulate PLEKHA3-Golgi association
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS