basic FUNCTION
| required for multiple TLR responses (Takahashi 2007) |
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regulates the subcellular distribution and response of multiple TLRs and is required for both innate and adaptive immune responses (Takahashi 2007) |
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chaperone-like endoplasmic reticulum (ER)-resident protein required for the proper subcellular distribution of multiple TLRs (Kiyokawa 2008) |
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with HSP90B1, differentially regulate TLR4 translocation to the cell surface (Saitoh 20009) |
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with UNC93B1, and HSP90B21, play a role in TLR localisation (McGettrick 2010) |
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CNPY3 is a TLR-specific cochaperone for HSP90B1 |
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distinct roles for CNPY3 and CNPY4 in the regulation of TLR1 surface expression |
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TLR1, TLR2 and TLR6 were expressed on the surface of B cells, monocytes and dendritic cells in a manner dependent on TLR-specific chaperone CNPY3 |
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co-chaperone in the endoplasmic reticulum that regulates the subcellular distribution and responses of multiple Toll-like receptors |
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perform essential roles in brain function in addition to known Toll-like receptor-dependent immune responses |