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FLASH GENE
Symbol PNLIPRP1 contributors: - updated : 06-07-2004
HGNC name pancreatic lipase-related protein 1
HGNC id 9156
Location 10q26.12      Physical location : 118.350.489 - 118.368.686
Synonym symbol(s) PLRP1
EC.number 3.1.1.3
DNA
TYPE functioning gene
STRUCTURE 18.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepancreas exocrine    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 17 amino acid hydrophobic signal peptide
  • a signal peptidase cleavage sequence G/KEV
  • a PLAT/LH2 domain
    • isoforms Precursor 450 aa for the mature form
    HOMOLOGY
    interspecies homolog to murine Pnliprp1
    Homologene
    FAMILY AB hydrolase superfamily, lipase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text secreted protein
    basic FUNCTION
  • hydrolyzes dietary triglycerides into diglycerides
  • active in pancreas
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS