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FLASH GENE
Symbol KRT23 contributors: mct/npt - updated : 27/09/2008
HGNC name keratin 23 (histone deacetylase inducible)
HGNC id 6438
Location 17q21.2      Physical location : 39.078.951 - 39.093.836
Synonym name
  • cytokeratin 23
  • keratin, type I cytoskeletal 23
  • hyperacetylation-inducible type I keratin
  • Synonym symbol(s) K23, DKFZP434G032, HAIK1, CK23, MGC26158
    DNA
    TYPE functioning gene
    STRUCTURE 14.90 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text alternative splicing results in multiple transcripts variants
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 splicing 2163 48 422 - Zhang, Schweizer (2006)
    - splicing 1474 - 209 - Zhang, Schweizer (2006)
    variant 2 has an alternative segment in 5'UTR, lacking a coding exon and using a downstream start codon. Isoform b has a shorter N-terminus as compared to isoform a
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta  highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a rod domain
  • mono polymer heteromer , tetramer , complex
    HOMOLOGY
    Homologene
    FAMILY
  • intermediate filament family
  • type I keratin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • responsible for the structural integrity of epithelial cells
  • epithelial keratins associated with simple/glandular or stratified, non-cornified epithelia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by thrichostatin A
    histone deacetylase inhibitors (sodium butyrate NaBu) in pancreatic cancer cells
    p21 (itself induced by Nabu)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS