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FLASH GENE
Symbol UMPS contributors: mct - updated : 22-05-2013
HGNC name uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)
HGNC id 12563
Corresponding disease
ODC orotic aciduria II
UMPS orotic aciduria I
Location 3q21.2      Physical location : 124.449.212 - 124.468.117
Synonym name
  • multifunctional protein uridine 5-primer monophosphate synthase
  • orotate phosphoribosyltransferase
  • Synonym symbol(s) URIC, OPRT, ODC, OK/SW-cl.21
    EC.number 2.4.2.10, 4.1.1.23
    DNA
    TYPE functioning gene
    STRUCTURE 18.91 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 6738 - 480 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  moderately
    Lymphoid/Immunelymph node   moderately
    Reproductivefemale systemovary  moderately
     female systemplacenta  moderately
     female systemuteruscervix highly
    Skin/Tegumentskin   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    Muscular    
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to rattus Umps_predicted
    ortholog to murine Umps
    Homologene
    FAMILY
  • purine/pyrimidine phosphoribosyltransferase family (for the N ternimal region)
  • OMP decarboxylase family (for the C ternimal region)
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • acting as an orotate phosphoribosyltransferase
  • acting as an orotidine-5'-phosphate decarboxylase
  • involved in early events of pancreatic and gallbladder carcinogenesis and invasion of involved in early events of pancreatic and gallbladder carcinogenesis and invasion of HCC.
  • fundamental enzyme in pyrimidine synthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
  • pyrimidine biosynthesis
  • UMP biosynthesis
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) UMPS , ODC
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hormone-refractory prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • high UMPS expression predicts complete response to chemoradiotherapy in patients with squamous cell carcinoma of the esophagus
  • Therapy target
    ANIMAL & CELL MODELS