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FLASH GENE
Symbol SLC39A6 contributors: mct - updated : 12-11-2021
HGNC name solute carrier family 39 (zinc transporter), member 6
HGNC id 18607
Location 18q12.2      Physical location : 33.688.494 - 33.709.357
Synonym name
  • LIV-1 protein, estrogen regulated
  • ermelin, endoplasmic reticulum membrane protein
  • solute carrier family 39 (metal ion transporter), member 6
  • Zrt- and Irt-like protein 6
  • estrogen-regulated protein LIV-1
  • zinc transporter ZIP6
  • Synonym symbol(s) LIV-1, ZIP6, LIV1
    DNA
    TYPE functioning gene
    STRUCTURE 20.86 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3637 - 755 - 2021 32797246
    8 - 1681 - 433 - 2021 32797246
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrine    
    Hearing/Equilibriumearinnercochlea  
    Nervousbrainbasal nucleicorpus callosum  
     brainhindbraincerebellum  
     braindiencephalonhypothalamus  
    Reproductivefemale systemplacenta   
     female systembreast   
     male systemtestis   
     male systemprostate   
    Urinarykidney    
    cell lineage
    cell lines HeLa and lung carcinoma
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a potential metalloprotease motif (HEX P H E XGD), which fits the consensus sequence for the catalytic zinc-binding site motif of the zincin metalloproteases
  • two histidine-rich sequences
  • a HELP domain
  • HOMOLOGY
    interspecies ortholog to murine Slc39a6
    ortholog to rattus Slc39a6_predicted
    Homologene
    FAMILY
  • ZIP transporter (tc 2.a.5) family
  • KE4/catsup subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • would be involved in heavy metal ion transport
  • may be a suitable prognostic marker for lymph-node involvement and a key determinant of metastatic spread in steroid hormone receptor-positive disease
  • tumor-promoting role for SLC39A6 in ESCC
  • zinc entry into activated lymphocytes depends on SLC39A6 and this transporter is essential for the correct function of the cellular activation machinery
  • SLC39A10/SLC39A6 heteromer is essential for the zinc-mediated trigger of mitosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text may be a zinc transporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    induced by oestrogen treatment
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in oestrogen-positive breast cancer with metastasis
    constitutional       gain of function
    strongly upregulated early during T cell activation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could serve as an early detector of high-risk subjects and prognostic biomarker in Esophageal squamous cell carcinoma (ESCC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveoesophagus
    targeting of SLC39A6 might be a potential therapeutic strategy for blocking ESCC
    ANIMAL & CELL MODELS