SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
|
| intracellular,cytoplasm,organelle,mitochondria
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endosome
|
| intracellular,cytoplasm,organelle,lysosome
|
text
| may localize to acidic late endosomes, lysosomes and mitochondria |
basic FUNCTION
| transports hydrophilic nucleosides, nucleobases and nucleoside analogue drugs across cell membranes |
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functions as a pH-dependent transporter of nucleosides across the lysosomal membrane |
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late endosomal/lysosomal transporter involved in the export of nucleosides from the lysosomal interior |
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having broad nucleoside selectivity (uridine, ademosine and cytidine) and most likely functioning to transport nucleosides across intracellular membranes, in acidic, intracellular compartments |
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involved in mitochondrial transport and may play an important role in mediating clinically observed mitochondrial toxicity of nucleoside drugs |
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playing a role in glucose metabolism is a priority for diabetes research |
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acidic pH-dependent nucleoside transporter |
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essential transmembrane transporter to maintain lysosome integrity by regulating nucleoside trafficking |
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potential role in the control of osteoclast differentiation and function |