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FLASH GENE
Symbol KIF24 contributors: npt/shn - updated : 22-03-2012
HGNC name kinesin family member 24
HGNC id 19916
Location 9p13.3      Physical location : 34.252.378 - 34.329.198
Synonym name
  • chromosome 9 open reading frame 48
  • kinesin-like protein KIF24
  • Synonym symbol(s) FLJ10933, bA571F15.4, C9orf48, MGC125677, MGC125678, FLJ43884
    DNA
    TYPE functioning gene
    STRUCTURE 76.81 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D9S1817 - D9S1805 - KIF24 - D9S1804 - D9S1794 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 6237 - 1368 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   lowly Homo sapiens
    Reproductivemale system   moderately Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to Kif24, Mus musculus
    ortholog to KIF24, Pan troglodytes
    Homologene
    FAMILY
  • kinesin-like protein family
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION
    text mother centrioles (
    basic FUNCTION
  • depolymerizes microtubules in vitro and ectopic expression of KIF24 leads to remodeling of centriolar microtubules
  • enriched at the mother centriole
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text remodeling centriolar microtubules and regulating cilia assembly (
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • KIF24 specifically interacts with CCP110 and CEP97, centrosomal proteins that play a role in regulating centriolar length and ciliogenesis
  • cell & other microtubules (
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism SNP
  • rs17350674 polymorphism may be a risk factor for sporadic Frontotemporal Lobar Degeneration (
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Loss of Kif24 from cycling cells resulted in aberrant cilia assembly but did not promote growth of abnormally long centrioles (