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FLASH GENE
Symbol OPALIN contributors: mct/npt - updated : 12/09/2008
HGNC name oligodendrocytic myelin paranodal and inner loop protein
HGNC id 20707
Location 10q23-q24      Physical location : 98.102.976 - 98.119.092
Synonym name transmembrane protein 10
Synonym symbol(s) TMP10, HTMP10, TMEM10
DNA
TYPE functioning gene
STRUCTURE 16.12 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3590 15.7 141 - Aruga (2007)
4 - 3521 - 118 - Aruga (2007)
7 - 3629 - 131 - Aruga (2007)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonhypothalamus  
 braindiencephalonamygdala  
 spinal cord    
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousoligodendrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • short extracellular domain having N- and O-glycan chains exposed to the intermembranous space between paranodal loops, and a fraction of the O-glycans is sialylated
  • long intracellular domain contains many consensus sites for protein phosphorylation
  • HOMOLOGY
    interspecies homolog to porcine Tmp83.5
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    text type-1 transmembrane sialylglycoprotein
    basic FUNCTION
  • playing a role in an intermembranous function of the myelin paranodal loops in the central nervous system
  • may be playing a role in intermembranous recognition or intracellular signaling in the cytoplasm-filled paranodal loops
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by regulated, at least in part, by intronic enhancer elements including the binding sites for myelin transcription factor 1 and cAMP-response element-binding protein
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    at the postnatal myelination stage and it predominantly distributes throughout the myelin-rich regions of the CNS, but not the PNS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS