basic FUNCTION
| involved in pancreas development and in beta cell function |
|
belonging to a functionally important complex of proteins of the glomerular filtration barrier |
|
with LRRC7, can act as autoantigens, and autoantibodies against these can be detected in patients with type 1 diabetes |
|
with NPHS1 could interact homophilically and heterophilically, suggesting that NPHS1 and KIRREL2 might regulate certain developmental aspects of PTF1A-positive neurons as homo- or heterooligomers |
|
nephrin and KIRREL or KIRREL2 trans-interactions promote cell-contact formation, suggesting that they may also function together in slit diaphragm assembly |
|
KIRREL, KIRREL2, KIRREL3 and PICK1 synergistically regulate cell recognition and contact formation |