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FLASH GENE

Symbol

ATG10

contributors: mct - updated : 31-03-2020

HGNC name	ATG10 autophagy related 10 homolog (S. cerevisiae)
HGNC id	20315

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q14.1      Physical location : 81.267.843 - 81.551.211
Synonym name	ATG10 autophagy related 10 homolog
	APG10 autophagy 10-like
	ubiquitin-like-conjugating enzyme ATG10
Synonym symbol(s)	APG10L, FLJ13954, DKFZP586I0418, pp12616, APG10

DNA

TYPE	like-sequence
STRUCTURE	286.48 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_031482 8 - 3029 NP_113670 - 184 - 2020 31996071 ATG10S ATG10S is a transcription factor competes with IRF1 for the same binding site to promote IFNL2 gene transcription promotes a complete autophagy process, leading to the degradation of HCV-subgenomic replicon and HCV genome (hepatitis C virus) IFNL2 might mediate the autophagosome docking to lysosomes, and ATG10S promoted the formation of autophagolysosomes with the help of IFNL2 NM_001131028 9 - 3164 NP_001124500 25.1 220 - 2003 12890687 ATG10L can facilitate HCV-subgenomic replicon amplification by causing impaired autophagy-flux

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system prostate

cells

System Cell Pubmed Species Stage Rna symbol Reproductive epithelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	autophagocytosis associated protein, C-terminal domain
	importance of two sulfhydryl groups on Cys44 and Cys135 in ATG10 protein

secondary structure

mutation or loss of Cys44 or/and Cys135 made ATG10 steric conformational change toward a ATG10S-like structure, rather than old disulfide bonds were disrupted and new ones reformed, leading to the similar ATG10S functions

HOMOLOGY

interspecies

homolog to S cerevisiae autophagy 10

Homologene

FAMILY

ATG10 family

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	play an important role in the invasion and proliferation of cancer cells, and bacterial infections
	might act as a latent transcription factor after losing its -SH group on Cys44 and/or Cys135
	is essential for autophagy since it promotes ATG5-ATG12 complex formation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	may be involved in ubiquitin cycle and protein transport

PATHWAY

metabolism

signaling

a component

native ATG10 protein generally exists as an oligomer manner in the autophagy process

INTERACTION

DNA

RNA

small molecule

protein	ATG10 interacts with ATG7 to receive an ubiquitin-like protein ATG12, recognizes both ATG12 and ATG5 directly and catalyzes their conjugation reaction
	autophagic E2 enzymes, ATG10, interacts with ATG7 to receive ATG12, a ubiquitin-like molecule, and is also involved in the ATG12-ATG5 conjugation reaction
	ATG10S as a transcription factor competes with IRF1 for the same binding site to promote IFNL2 gene transcription

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to development of hepatocellular carcinoma (HCC) to breast cancer

Variant & Polymorphism other	ATG10 rs1864183, ATG10 rs10514231 significantly associated with HCC risk
	rs1864182 and rs10514231 in ATG10 were significantly associated with a decreased risk of breast cancer

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology infectious   ATG10S might be a new host factor against HCV replication, and is a target for screening chemicals with new anti-virus mechanisms

ANIMAL & CELL MODELS