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FLASH GENE
Symbol CCL17 contributors: mct/npt - updated : 24-03-2010
HGNC name chemokine (C-C motif) ligand 17
HGNC id 10615
Location 16q13      Physical location : 57.438.678 - 57.449.974
Synonym name
  • small inducible cytokine subfamily A (Cys-Cys), member 17
  • T cell-directed CC chemokine
  • small inducible cytokine A17
  • thymus and activation-regulated chemokine
  • CC chemokine TARC
  • Synonym symbol(s) TARC, ABCD-2, SCYA17, A-152E5.3, MGC138271, MGC138273
    DNA
    TYPE functioning gene
    STRUCTURE 11.30 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure two STAT6 motifs in the proximal promoter, additional element involved in the regulation of CCL17 expression (Maier 2007)
    MAPPING cloned Y linked N status confirmed
    Map cen - D16S2959 - CCL17 - D16S2941 - qter
    Authors Nomiyama (97)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 615 - 94 - Imai (1997)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Digestiveintestinelarge intestinecolon lowly
     intestinesmall intestine  lowly
    Respiratorylung   lowly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Ccl17
    Homologene
    FAMILY
  • intercrine beta family (small cytokine C-C) (chemokine CC)
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • chemoattractant for T cells, involved in mononuclear cell recruitment into atherosclerotic lesions and in inflammatory response
  • functions as a selective chemoattractant for T cells that express a class of receptors binding CCL17 with high affinity and specificity (Imai 1997)
  • plays a unique and essential role in cutaneous dendritic cells migration and the pathogenesis of allergic skin inflammation (Stutte 2010)
  • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS inflammation
    text inflammatory response
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to chemokine receptors CCR8
  • specific functional ligand for CCR4, and CCR4 is the specific receptor for CCL17 selectively expressed on T cells (Imai 1997)
  • interacting with TP63 (TP63 induces CD4+ T-cell chemoattractant CCL17 in human epithelial cells) (Kubo 2008)
  • cell & other
    REGULATION
    induced by phytohemagglutinin (in peripheral blood mononuclear cells)
    cytokines in monocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • local inhibition of CCL17 might be more suitable for prevention of allergic skin inflammation than CCR4 blockade (Stutte 2010)
  • ANIMAL & CELL MODELS