Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ANAPC4 contributors: mct - updated : 03-09-2010
HGNC name anaphase-promoting complex subunit 4
HGNC id 19990
Location 4p15.2      Physical location : 25.378.847 - 25.420.119
Synonym name cyclosome subunit 4
Synonym symbol(s) APC4
DNA
TYPE functioning gene
STRUCTURE 41.27 kb     29 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
29 - 2701 - 808 - Yu (1998)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
cell cycle     cell cycle, checkpoint, G2M
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Anapc4
Homologene
FAMILY
  • APC4 (anaphase-promoting complex) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • controlling progresion through anaphase by triggering the degradation of cell cycle regulators such securin and B-type cyclin
  • orchestrates progression through mitosis by decorating cell-cycle regulators with ubiquitin chains (Jin 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text ubiquitin dependent catabolism
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS