basic FUNCTION
| positive regulator of proteolysis |
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could be a potential useful target gene for anti-tumor drugs |
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involved in the destabilization of Aurora-A through the proteasome-dependent degradation pathway (Lim (2007) |
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functions in stabilizing rather than destabilizing Aurora-A (Katayama 2007) |
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promotes proteasome-dependent Aurora-A degradation through an Ub-independent mechanism (Lim 2007) |
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palying a a role for AIP in G2/M cell cycle progression by cooperatively regulating protein stabilization of its up-stream regulator, Aurora-A kinase through protein-protein interaction as well as protein phosphorylation (Katayama 2007) |