SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus,nucleoplasm
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basic FUNCTION
| playing a role in the recycling of the AT(1) receptor to the plasma membrane with presumable concomitant recovery of receptor signal functions |
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negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation or by receptor desensitization such as phosphorylation |
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inducing also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity |
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downregulating AT1R and attenuating certain angiotensin II-mediated hypertrophic responses in cardiomyocytes (Tanaka 2005) |
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adipose AGTRAP plays an important role in preventing metabolic disorders and adiponectin possibly mediates the effects of adipose AGTRAP |
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leukocyte AGTRAP is an emerging marker capable of reflecting the systemic and leukocyte inflammatory profile, and plays a role as an anti-inflammatory factor in the pathophysiology of hypertension, atherosclerosis and chronic kidney disease |
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renal proximal tubule ATRAP has a minor role in angiotensin-dependent hypertension |
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in addition to its conventional role in angiotensin signaling, AGTRAP also modulates presynaptic Ca2+ signaling within the central nervous system |