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FLASH GENE
Symbol AGTRAP contributors: SGE/mct - updated : 08-12-2020
HGNC name angiotensin II receptor-associated protein
HGNC id 13539
Location 1p36.22      Physical location : 11.796.141 - 11.810.827
Synonym name
  • ATI receptor-associated protein
  • angiotensin II type I receptor-associated protein
  • Synonym symbol(s) ATRAP, ARAP1, MGC29646
    DNA
    TYPE functioning gene
    STRUCTURE 14.69 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1200 - 159 - 2003 12960423
  • isoform a
  • 5 - 1179 - 152 - 2003 12960423
  • isoform b
  • 4 - 1144 - 111 - 2003 12960423
  • isoform c
  • 6 - 1276 - 155 - 2003 12960423
  • isoform d
  • 6 - 1297 - 147 - 2003 12960423
  • isoform e
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiens
     vesselaorta  highly Homo sapiens
    Endocrineadrenal gland   highly Homo sapiens
     pancreas   highly
    Nervousnervecranial nerve  highly
    Reproductivefemale systemuteruscervix highly
    Skin/Tegumentskin   highly
    Urinarykidneytubuleconvoluted tubuleproximal tubulehighly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumcardiacmyocardium  Homo sapiens
    Nervouscentral    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticgranulocyte Homo sapiens
    Blood/Hematopoieticmonocyte Homo sapiens
    Nervousoptic nerve Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Agtrap (75.5pc)
    homolog to murine Agtrap (77.4pc)
    Homologene
    FAMILY
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • playing a role in the recycling of the AT(1) receptor to the plasma membrane with presumable concomitant recovery of receptor signal functions
  • negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation or by receptor desensitization such as phosphorylation
  • inducing also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity
  • downregulating AT1R and attenuating certain angiotensin II-mediated hypertrophic responses in cardiomyocytes (Tanaka 2005)
  • adipose AGTRAP plays an important role in preventing metabolic disorders and adiponectin possibly mediates the effects of adipose AGTRAP
  • leukocyte AGTRAP is an emerging marker capable of reflecting the systemic and leukocyte inflammatory profile, and plays a role as an anti-inflammatory factor in the pathophysiology of hypertension, atherosclerosis and chronic kidney disease
  • renal proximal tubule ATRAP has a minor role in angiotensin-dependent hypertension
  • in addition to its conventional role in angiotensin signaling, AGTRAP also modulates presynaptic Ca2+ signaling within the central nervous system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with GNB2L1/RACK1, and with the C-terminal region of AGTR1
  • interaction with CAMLG may mediate the AGT actions in vascular physiology
  • may serve as a local modulator of vascular AGTR1 function
  • AGTRAP is a molecule specifically interacting with the carboxyl- terminal domain of AGTR1
  • AGTRAP enhances the activity of ATP2A2 and, consequently, facilitates ventricular relaxation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • dysregulated levels of the AGTRAP may be involved in sepsis pathophysiology and may be utilized as potential diagnostic biomarkers
  • Therapy target
    SystemTypeDisorderPubmed
    miscelleaneoushypertension 
    AGTRAP-mediated modulation of sodium handling in renal distal tubules could be a target of interest in salt-sensitive blood pressure regulation
    ANIMAL & CELL MODELS