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FLASH GENE
Symbol WDR19 contributors: mct - updated : 24-05-2022
HGNC name WD repeat domain 19
HGNC id 18340
Corresponding disease
CETD4 cranioectodermal dysplasia 4
NPHP13 nephronophthisis 13
SLSN8 Senior-Loken syndrome 8
SPGF72 spermatogenic failure 72
SRPS7 short rib-polydactyly syndrome type VII
Location 4p14      Physical location : 39.184.023 - 39.287.429
Synonym name
  • WD repeat membrane protein PWDMP 2
  • WD repeat membrane protein PWDMP
  • intraflagellar transport 144 homolog
  • Synonym symbol(s) KIAA1638, FLJ23127, ORF26, PWDMP, DYF-2, FLJ23127, IFT144, Oseg6
    DNA
    TYPE functioning gene
    STRUCTURE 103.28 kb     37 Exon(s)
    regulatory sequence Promoter (TATA box)
    Binding site
    text structure binding sites for AP1and SP1
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1800 - - normal prostate,pancreas 2013 23683095
    37 - 4395 - 1342 - 2013 23683095
    - - 6800 - - normal prostate, testis, ovary 2013 23683095
    36 - 4279 - 1182 - 2013 23683095
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemprostate    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveepithelial cell Homo sapiens
    cell lineage
    cell lines prostate carcinoma cell line
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six WD repeats
  • a transmembrane spanning region
  • a CHCR domain and a vacuolar-targeting motif
  • HOMOLOGY
    interspecies ortholog to murine Dyf-2
    Homologene
    FAMILY WD repaet-containing protein family
    CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • may be involved in vacuole generation and transport
  • localizes to cilia, pointing to an important evolutionarily conserved role for this WDR protein in cilia development and function
  • prostate-specific, androgen-regulated gene
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • member of the intraflagellar transport (IFT) complex A that drives retrograde ciliary transport
  • IFT-A protein complex consists of IFT43, WDR35, IFT122, TTC21B, IFT140 and WDR19 and is associated with THM1 and TULP3
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is essential for functional IFT-A assembly and ciliary entry of GPCRs but dispensable for anterograde IFT-B trafficking
  • cell & other
    REGULATION
    Other regulated by androgens in prostate epithelium expression
    ASSOCIATED DISORDERS
    corresponding disease(s) CETD4 , SRPS7 , SLSN8 , NPHP13 , SPGF72
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS