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FLASH GENE
Symbol CCZ1 contributors: mct - updated : 21-10-2011
HGNC name CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
HGNC id 21691
Location 7p22.1      Physical location : 5.938.340 - 5.965.601
Synonym name
  • chromosome 7 open reading frame 28A
  • hypothetical protein LOC51622
  • Synonym symbol(s) CGI-43, DKFZP586I1023, C7orf28A, H_DJ1163J12.2, H_NH0577018.2
    DNA
    TYPE functioning gene
    STRUCTURE 27.27 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 1834 - 482 - 2010 20305638
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • UPF0550 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • required for fusion of various transport intermediates with the vacuole
  • MON1A and CCZ1 are critical and evolutionarily conserved components regulating the processing of ingested apoptotic cell corpses
  • seems to act in lysosome biogenesis and phagosome maturation by recruiting the GTPase RAB7A7 over the phagosome
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MON1A-CCZ1 complex triggers endosomal maturation by activating RAB7A7 on late endosomes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS