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FLASH GENE
Symbol MASTL contributors: mct/ - updated : 11-10-2010
HGNC name microtubule associated serine/threonine kinase-like
HGNC id 19042
Corresponding disease
THC2 thrombocytopenia 2
Location 10p12.1      Physical location : 27.443.752 - 27.475.848
Synonym name
  • Greatwall
  • hypothetical protein FLJ14813
  • Synonym symbol(s) FLJ14813, GWL, RP11-85G18.2
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 32.13 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3626 97.2 879 - - 12890928
    12 - 3623 97 878 - - 12890928
    - - 3509 92.7 840 - - 12890928
    EXPRESSION
    Rna function mRNA is restricted in its expression to hematopoietic and cancer cell lines
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Respiratorylung    
    Visualeyeuveachoroid  
     eyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    Epithelialbarrier/liningendometrium  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • serine/Threonine protein kinases, catalytic domain
  • one response regulatory domain
  • a very long T-loop (>500 AAs) that separates the kinase subdomains VII and VIII, a particular feature exclusive to Gwl kinases
  • HOMOLOGY
    interspecies ortholog to murine Mastl
    ortholog to ortholog of drosophila Greatwall protein kinase
    Homologene
    FAMILY
  • AGC family of serine/threonine kinases that phosphorylates substrates on S/T residues encircled by basic amino acids
  • CATEGORY receptor membrane serine/threonine kinase
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text
  • localizes to the nucleus in interphase and re-localizes in part to centrosomes in mitosis, when it is active
  • basic FUNCTION
  • involved in the activation of a meiotic genes activation pathway
  • promotes mitotic entry and maintenance in human cells by inhibiting protein phosphatase 2A (PP2A)
  • crucial for mediating this regulation in somatic human cells
  • mediates mitotic entry and maintains the mitotic state by inhibiting PP2A, and thus maintains the correct equilibrium between cyclin B-Cdc2 and PP2A
  • essential kinase for correct chromosome condensation and mitotic progression
  • enhances cyclin B1-Cdk1-dependent mitotic phosphorylation events, directing mitotic entry, anaphase and cytokinesis
  • phosphorylating in mitosis ENSA, converting ENSA into a potent and specific inhibitor of PPP2R2B/PPP2R2D
  • is required to maintain mitosis through PPP2R2B inhibition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
  • ENSA and ARPP19 are substrates of MASTL
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) THC2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    results in G2 arrest and multiple mitotic defects
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS