basic FUNCTION
| playing a role in hormonally regulated, chromatin-mediated regulation of transcription |
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only NURF-specific subunit of NURF and is instrumental in recruiting the complex to target genes (Kwon 2009) |
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required for spermatogenesis (Kwon 2009) |
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maintains chromatin accessibility and the self-renewal capacity of mammary gland stem cells |
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critical for the homeostasis of T cells via a cell-intrinsic manner, and essential for the maintenance and function of regulatory T (Treg) cells |
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vital role for BPTF in T and Treg cell function and immune homeostasis |
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is essential for the formation of mesoderm, endoderm, and differentiated ectoderm lineages and is required for the establishment of the embryonal anterior-posterior axis during early development |