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FLASH GENE
Symbol HERC4 contributors: mct - updated : 28-08-2020
HGNC name hect domain and RLD 4
HGNC id 24521
Location 10q21.3      Physical location : 69.681.656 - 69.835.103
Synonym name ubiquitin-protein ligase E3A
Synonym symbol(s) KIAA1593
EC.number 2.3.2.26
DNA
TYPE functioning gene
STRUCTURE 153.42 kb     29 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
26 splicing 4448 - 1057 - 2019 31010679
25 splicing 4424 - 1049 - 2019 31010679
24 splicing 4214 - 979 - 2019 31010679
24 - 4172 - 794 - 2019 31010679
4 - 3385 - 110 - 2019 31010679
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Lymphoid/Immunethymus    
Nervousbrain    
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/liningepidermis  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye, brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one HECT type E3 ubiquitin-protein ligase domain
  • one RCC1 domain
  • HOMOLOGY
    Homologene
    FAMILY HERC family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • involved in protein modification, ubiquitin cycle
  • potential positive feedback loop, where Hippo stabilises its own positive regulator by antagonising HERC4-mediated degradation of SAV1
  • HERC4 plays a role in cell proliferative and migration ability
  • has an effect on the occurrence and development of hepatoma carcinoma by promoting hepatoma carcinoma cell proliferation and migration, and by reducing cell apoptosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HERC4, which binds to SMO, and regulates HH signalling by controlling SMO ubiquitination and degradation
  • HERC4 acts as a tumor suppressor via destabilizing the oncoprotein SMO
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in Hepatocellular Carcinoma
    tumoral     --over  
    in breast cancer cell lines and breast tumor tissues compared to non-tumorigenic cell line and adjacent normal breast tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • significant diagnostic marker for invasive ductal carcinoma of the breast
  • Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    is a promising therapeutic target for NSCLC treatment
    ANIMAL & CELL MODELS