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FLASH GENE

Symbol

DDX23

contributors: mct/npt - updated : 01-07-2010

HGNC name	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
HGNC id	17347

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q13.12      Physical location : 49.223.539 - 49.245.957
Synonym name	PRP28 homolog, yeast
	U5 snRNP 100 kD protein
	DEAD box protein 23
	100 kDa U5 snRNP-specific protein
Synonym symbol(s)	PRP28, U5-100K, PRPF28, MGC8416
EC.number	3.6.1.-

DNA

TYPE	functioning gene
STRUCTURE	22.42 kb     17 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004818 17 - 3288 NP_004809 - 820 - Teigelkamp (1997)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Nervous brain

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial sensory olfactory

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one helicase ATP-binding domain
	one helicase C-terminal domain

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to yeast Prp28
	homolog to murine Ddx23 (98.7pc)
	homolog to rattus Ddx23 (98.7pc)

Homologene

FAMILY	DEAD box helicase family
	DDX23/PRP28 subfamily

CATEGORY

regulatory , RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	having helicase, ATP binding, ATP dependent helicase activities
	having function in spliceosome assembly (Mathew 2008)
	may facilitate conformational changes in the spliceosome during pre-mRNA splicing

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	spliceosome component required for splicing of nuclear pre-mRNA
	component of the U5 snRNp complex

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP binding

protein

interaction with SRPK2 (role for SRPK2 in splicing and in spliceosome assembly) (Mathew 2008)

cell & other

REGULATION

Other

phosphorylation is required for its spliceosomal B complex association (Gustafson 2010)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS