basic FUNCTION
| playing a necessary role for neural development |
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involved in neural development, and functioning as a negative regulator of BMP signaling |
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promotes BMPR degradation via the lipid raft-caveolar pathway |
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dephosphorylates LPIN1, LPIN2, LPIN3, and potentially participates in a unique phosphatase cascade regulating nuclear membrane biogenesis, cascades conserved from yeast to mammals ( |
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having specificity for the peptide corresponding to the insulin-dependent phosphorylation site (Ser106) of lipin |
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is essential for ovarian homeostasis at least in part via suppression of BMP signaling |
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CTDNEP1, controls de novo glycerolipid synthesis through lipin to prevent invasion of excess ER membranes into NE holes and a defective nuclear envelope (NE) permeability barrier |
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CTDNEP1-EPS8L2 interaction regulates likely dorsal actin cables for nuclear movement during cell migration |
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CTDNEP1 is a tumor suppressor in highly aggressive MYC-driven medulloblastomas by controlling MYC activity and mitotic fidelity |