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FLASH GENE
Symbol DHX36 contributors: mct - updated : 07-03-2013
HGNC name DEAH (Asp-Glu-Ala-His) box polypeptide 36
HGNC id 14410
Location 3q25.2      Physical location : 153.993.457 - 154.042.286
Synonym name
  • RNA helicase associated with AU-rich element ARE
  • G4 resolvase-1
  • MLE-like protein 1
  • Synonym symbol(s) DDX36, MLEL1, KIAA1488, G4R1, RHAU
    EC.number 3.6.4.13
    DNA
    TYPE functioning gene
    STRUCTURE 48.83 kb     25 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 3625 114.6 1008 - 2003 12782131
    25 - 3583 113 994 - 2003 12782131
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
    Respiratorylung    
    Visualeyelens   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text spleen
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region is essential for binding G4 structures and further identify within this region the evolutionary conserved RSM (RHAU-specific motif) domain as a major affinity and specificity determinant
  • two DRBM (double-stranded rna-binding) domains
  • HOMOLOGY
    Homologene
    FAMILY
  • DEAD box helicase family
  • DEAH subfamily
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be playing a role in X-linked gene expression
  • is responsible for the majority of tetramolecular G4-DNA resolvase activity
  • fourth RNA helicase detected in stress granules (SGs), after DDX6, DDX3, and EIF4A, and its association with SGs is dynamic and mediated by an DHX36-specific RNA-binding domain
  • its helicase activity is sufficient to unwind the quadruplex and promote an interaction with 25 internal nucleotides to form a stable P1 helix
  • is the only helicase having G-quadruplex (G4)-RNA resolvase activity and the major source of G4-DNA resolvase activity
  • may potentially play a role in the regulation of gene expression that relies on its G4 resolvase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • DDX1-DDX21-DHX36 complex represents a dsRNA sensor that uses the TICAM1 pathway to activate type I IFN responses in the cytosol of myeloid dendritic cells (mDCs)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the N-terminal accessory domain of DHX36 known to bind specifically to the parallel-strand G-quadruplex substrates resolved by the helicase domain
  • TERC is a true target of DHX36
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS