basic FUNCTION
| involved in neurotransmitter release by stimulating SNARE complex formation |
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inhibiting the priming step and impairing the efficiency of vesicle pool refilling in a calcium-dependent manner |
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neural tissue-specific syntaxin-1-binding protein, which is capable of dissociating STXBP1 from syntaxin-1 to form a 10S tomosyn complex |
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involved in a post-docking event that prepares secretory granules for fusion and is necessary to sustain exocytosis of pancreatic beta-cells in response to insulin secretagogues |
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inhibits SNARE complex formation and neurotransmitter release by sequestering syntaxin-1 through its C-terminal vesicle-associated membrane protein (VAMP)-like domain (VLD) |
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negative regulator of neurotransmitter release, that inhibit SNARE complex formation by sequestering target SNAREs (VTI1A) upon interaction of its C-terminal VAMP-like domain with VTI1A |
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may be controling synaptic vesicle fusion positively by serving as a placeholder for VAMP2 |
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negatively regulates Ca2+-dependent neurotransmitter release by sequestering target SNAREs through the C-terminal VAMP-like domain |
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multiple domains outside the R-SNARE of STXBP5 are critical to the efficacy of inhibition by tomosyn on exocytotic secretion |
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syntaxin-binding protein, known to inhibit vesicle priming and synaptic transmission via interference with the formation of SNARE complexes |
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roles for tomosyn1 in hippocampus-dependent spatial learning and memory |
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facilitates granule release from platelets, but it inhibits secretion from the Weibel-Palade bodies (WPBs) of endothelial cells |
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is required for normal arterial hemostasis, due to its contributions to platelet granule cargo packaging and secretion |
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inhibits endothelial exocytosis but promotes platelet secretion |
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STXBP5L and STXBP5 regulate docking and fusion of synaptic vesicles with the presynaptic membrane, a process of crucial importance for normal neurotransmission |