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FLASH GENE
Symbol RAD54L2 contributors: mlc/np - updated : 17-11-2007
HGNC name RAD54-like 2 (S. cerevisiae)
HGNC id 29123
Location 3p21.31-p21.2      Physical location : 51.575.595 - 51.697.610
Synonym name
  • likely ortholog of mouse steroid receptor-interacting SNF2 domain protein
  • AR (androgen receptor)-interacting protein 4
  • KIAA0809 protein
  • RAD54-like 2
    • Synonym symbol(s) SRISNF2L, KIAA0809, ARIP4, FLJ21396, FLJ22400, HSPC325
    DNA
    TYPE functioning gene
    STRUCTURE 35.00 kb     20 Exon(s)
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 4319 151 1359 - Lim (2006)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Nervousnerve   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region mediating interaction with AR
    • HOMOLOGY
    interspecies ortholog to murine Srisnf2l-pending
    Homologene
    FAMILY
    CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • acting as an helicase
  • active ATPase, and dsDNA (double-stranded DNA) and ssDNA (single-stranded DNA) enhancing its catalytic activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule nucleotide,
    ATP
    protein
  • interacts with AR and binds to DNA and mononucleosomes
    • cell & other
    REGULATION
    Other covalently modified by sumoylation, and mutation of six potential SUMO (small ubiquitin-related modifier) attachment sites abolished its ability to bind DNA, hydrolyse ATP and activate AR function
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS