basic FUNCTION
| catalyzes unwinding of the U4/U6 RNA duplex in the spliceosome (Laggerbauer et al, 1998) |
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RNA helicase involved in the second step of RNA splicing |
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promoting one or more coformational changes in the dynamic network of RNA-RNA interactions in the spliceosome |
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plays a central and conserved role in nuclear pre-mRNA splicing (Zhao 2009) |
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its function is necessary for unwinding the U4/U6 duplex, a step essential for catalytic activation of the spliceosome (Maeder 2009) |
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essential for U4/U6 di-small nuclear ribonucleoprotein disruption during spliceosome catalytic activation and for spliceosome disassembly, and is the only member of this group that is permanently associated with the spliceosome, thus requiring its faithful regulation |
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Ski2-like RNA helicase , and core component of the spliceosome that must be tightly regulated to ensure correct timing of spliceosome activation |
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DExD/H box RNA helicase crucial for pre-mRNA splicing |
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is required for the assembly of a catalytically active spliceosome on a messenger RNA precursor |
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SNRNP200 helicase provides the key remodeling activity for spliceosome catalytic activation, during which it disrupts the U4/U6 di-snRNP (small nuclear RNA protein), and its activity has to be tightly regulated |
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novel immunoregulatory role of the spliceosomal SNRNP200 helicase as an RNA sensor and TBK1 adaptor for the activation of IRF3-mediated antiviral innate response |
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pre-mRNA splicing factor PRPF8 is a crucial component of the U5 snRNP, and together with EFTUD2 and SNRNP200, it forms a central module of the spliceosome |