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FLASH GENE
Symbol MTUS2 contributors: mct/pgu - updated : 06-04-2013
HGNC name microtubule associated tumor suppressor candidate 2
HGNC id 20595
Location 13q12.3      Physical location : 29.598.747 - 30.080.083
Synonym name
  • hypothetical protein LOC23281
  • cardiac zipper protein
  • microtubule plus-end tracking protein TIP150
  • microtubule-associated tumor suppressor candidate 2
  • tracking protein of 150 kDa
  • Synonym symbol(s) TIP150, KIAA0774, CAZIP, ICIS
    DNA
    TYPE functioning gene
    STRUCTURE 481.30 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 6957 - 1379 - -
  • isoform a
  • 9 - 4009 40.6 348 - -
  • isoform b
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Mus musculusFetalmRNA
     heart     Mus musculusAdult
    Nervousbrain     Mus musculusFetalmRNA
     brain     Mus musculusAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a leucine-zipper domain at the C-terminus
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text colocalizes with MAPRE1 at the microtubule plus end
    basic FUNCTION
  • facilitating the MAPRE1-dependent loading of KIF2C onto microtubule plus ends and orchestrate the dynamics at the plus ends of microtubules
  • involved in the plus-end localization of KIF2C
  • potential role in development and function of the heart and nervous system in vertebrates
  • microtubule plus-end tracking protein
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to the mitotic centromere-associated kinesin KIF2C
  • interaction with MAPRE1 in loading of KIF2C to the plus ends
  • MAPRE1–MTUS2 interaction coordinates chromosome movements in mitosis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS