basic FUNCTION
| specifically demethylating Lys-9 of histone H3, thereby playing a central role in histone code |
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preferentially demethylating mono- and dimethylated H3 Lys-9 residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 Lys-9 |
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involved in hormone-dependent transcriptional activation, by participating to recruitment to androgen-receptor target genes, resulting in H3 Lys-9 demethylation and transcriptional activation |
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may play a role in the ontogeny of white blood cells |
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may be playing a key role in maintenance of embryonic stem cell self-renewal and is a direct target of POU5F1 signaling |
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exhibits hormone-dependent recruitment to androgen-receptor target genes, resulting in H3K9 demethylation and transcriptional activation |
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histone H3K9 demethylase implicated in the nuclear hormone receptor-based transcriptional regulation |
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regulating the expression of ADM and GDF15 under hypoxia by decreasing promoter histone methylation |
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plays a role in regulating fat metabolic gene expression in muscle and brown fat tissue |
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KMD3A-controlled epigenetic histone modifications are crucial for Crem-regulated gene expression and spermatogenesis |
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mainly located around blood vessels which indicated that KDM3A is involved tumor angiogenesis |
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elevated expression of KDM3A plays a critical role in the growth of cancer cells |
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importance of a single amino acid in KDM3A implicated in the catalytic activity towards H3K9me1/2 that is not conserved in JMJD1C |
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is a new, miR-regulated, tumor promoter in Ewing Sarcoma |
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is required for male fertility, sex determination, and metabolic homeostasis through its nuclear role in chromatin remodeling |
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YBX2 and KDM3A genes may play an important role in male infertility |
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KDM3A, KDM3B meditated H3K9 demethylation has critical roles for early embryogenesis and embryonic stem cells (ESCs) maintenance |