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FLASH GENE
Symbol TOX4 contributors: mct - updated : 13-10-2010
HGNC name TOX high mobility group box family member 4
HGNC id 20161
Location 14q11.2      Physical location : 21.945.334 - 21.967.317
Synonym name
  • chromosome 14 open reading frame 92
  • epidermal Langerhans cell protein LCP1
  • KIAA0737
  • migration-inducing protein 7
  • Synonym symbol(s) KIAA0737, C14orf92, LCP1, MIG7
    DNA
    TYPE functioning gene
    STRUCTURE 21.99 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 4538 66 621 - 2010 20516061
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrinepancreas   highly
    Nervousbrain   predominantly
    Reproductivefemale systemovary  highly
     male systemtestis  highly
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • HMG box DNA-binding domain
  • C-terminus sufficient for the interaction with an N-terminal region of PPP1R10 that is distinct from its PP1-binding domain
  • HOMOLOGY
    Homologene
    FAMILY HMG-box protein family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in transcription regulation
  • potential role of the PTW/PP1 phosphatase complex in the regulation of chromatin structure during the transition from mitosis into interphase
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component stable multimeric complex composed of regulatory subunits PPP1R10, TOX4, and WDR82 , and PPP1CC catalytic subunit (denoted as the PTW/PP1 phosphatase complex)
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with PPP1R10 (transcriptional activity of TOX4 is markedly suppressed by its interaction with PPP1R10, in a PP1-independent manner)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS