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FLASH GENE
Symbol YEATS4 contributors: mct - updated : 18-06-2019
HGNC name YEATS domain containing 4
HGNC id 24859
Location 12q13-q15      Physical location : 69.753.531 - 69.784.575
Synonym name
  • NUMA binding protein 1
  • glioma-amplified sequence-41
    • Synonym symbol(s) NUBI-1, GAS41
    DNA
    TYPE functioning gene
    STRUCTURE 31.00 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to S cerevisiae Anc1
    ortholog to murine Yeats4
    intraspecies homolog to MLLT3,MLLT1
    Homologene
    FAMILY YEATS family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • having a transcription stimulatory activity
  • involved in regulation of transcription, DNA-dependent
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component SWI/SNF complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MLLT1, MLLT3, SMARCB1
  • YEATS4 is a histone acetylation reader that promotes histone H2AFZ deposition in non small cell lung cancer (NSCLC)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in low grade glioma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS