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FLASH GENE
Symbol RBAK contributors: SGE/npt - updated : 13-04-2010
HGNC name RB-associated KRAB zinc finger
HGNC id 17680
Location 7p22.1      Physical location : 5.085.552 - 5.109.119
Synonym name
  • RB-associated KRAB repressor
  • hRBaK
  • zinc finger protein 769
  • Synonym symbol(s) ZNF769
    DNA
    TYPE functioning gene
    STRUCTURE 23.57 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 6551 - 714 - Skapek (2000)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivefemale systemplacenta   
    Respiratorylung    
    Skeleton     
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneactivated B lymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 16 C2H2-type zinc fingers
  • one KRAB domain
  • HOMOLOGY
    interspecies homolog to murine Rbak (79.7pc)
    homolog to rattus Rbak (79.0pc)
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may contribute to RB-dependent suppression of E2F-mediated transcriptional activation and RB-mediated cell cycle arrest
  • may promote AR-dependent transcription (Hofman 2003)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    text transcriptional repressor
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+ binding
  • protein
  • interacting with RB1
  • interacting with AR (Hofman 2003)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism SNP RBaK (-)2031T/2030G/834C/821T alleles may have functional roles contributing to the FH-II phenotype (Jeske 2008)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS